Job Benefit: Dental

Quality Assurance Specialist

Job Title:  Quality Assurance Specialist

 

Reporting Relationships: Quality / Regulatory Manager

Status: Full-time, Exempt

Hours: Flexible, on-site/remote

Department: Quality Assurance

FLSA: Exempt

 

Job Summary & Purpose:

The Quality Assurance Specialist monitors conformance to quality assurance standards and established organizational procedures. Responsible for supporting and evolving formal quality processes, ensuring that the team is using industry-accepted best practices. Work closely with all manufacturing functions to execute assigned responsibilities and drive improvements to the methodologies and processes employed by these functions. Responsible for (and may not be limited to) quality functions listed below and identifying improvement opportunities for these functions.

Essential Functions:

·         Coordinate supplier management process, documentation and periodic updates to score cards.

·         Coordinate and maintain document control processes.

·         Coordinate and maintain training program.

·         Conduct nonconforming product inspections and facilitate disposition as needed.

·         Review batch records and quality certificates as needed.

·         Support quality functions such as deviations, CAPAs, audits, validations and equipment qualifications.

·         Drive quality records and investigations to a defined point of completion/closure.

·         Report regularly on trends and high-priority quality events.

·         Support change and transfer processes.

·         Stay current with all Regulatory Standards (and/or any other quality standards that affect the company and its customers) and how they apply to Grace Bio-Labs, particularly those which directly deal with your responsibilities.

·         Maintain confidentiality for all customer records and correspondence.

·         Mentor GBL team members in the use of the quality software systems.

·         Work safely and follow all safety protocols.

·         Communicate effectively and work well with others.

·         All other duties as assigned by manager / supervisor.

 

Minimum Qualifications:

·         Must have 4 years of on-the-job experience in one or more of the areas of the quality field.

·         Four-year college degree preferred, two-year associates degree minimum.

·         Statistical processing and interpretation of data (preferred).

·         Safety and regulatory requirements for the position (preferred).

·         Ability to multi-task/prioritize in an efficient and organized manner.

·         Use of business system software (proficient in MS Office).

·         Use of quality system software (preferred).

·         Ability to maintain a positive attitude amid potentially high-stress situations.

·         Outstanding communication skills.

·         A keen eye for detail and a results-driven approach.

Working Conditions:

 

·         Work will be in shared office space in a typical office environment

·         Some work will take place in the production environment.  Specialized attire is required in environmentally controlled spaces including scrubs, lab coat, hair net and other protective clothing.

 

Physical Demands & Work Environment:

 

·         Use of computer, phone, office equipment.

·         Odor free environment (smoke-free, fragrance free).

·         Long hours on a computer with typing and data entry. (Use of wrist and motor skills).

·         Represent GBL in a professional manner (attire, speech, and grooming).

·         Use of stairs as required.

Scientist, Cell Culture

Job Title: Scientist, Cell Culture

 

Reporting Relationships: R/D Manager

Status: Full-time, Exempt Hours: Flexible Department: R/D

FLSA: Exempt

 

Job Summary & Purpose:
The Scientist, Cell Culture will serve as a lead for all cell culture projects. The successful candidate will work cross-functionally with other members of the R&D team to ensure successful customer project outcomes. This highly motivated individual will plan, perform, report, present and trouble- shoot experiments under the guidance of a Senior Scientist or R/D Manager. Summarize and organize experimental data. Provide testing services and support production of immunoassay products including product information, manuals, technical support documents and pricing information.

 

Essential Functions:
·         Design and conduct complex experiments independently with scientific rationale

·         Participate in study execution and perform cell culture laboratory work

·         Immunohistochemistry assay development work

·         Analyze experimental data

·         Draft interim and final project reports

·         Identify and bring up project risks (critical path items, technical issues, etc.)

·         Collaborate and communicate with cross-functional teams to support product development and quality control deliverables

·         Present study results internally and externally

·         Proactively share own experience and standard methodologies with team members. Provide timely feedback to others

·         Work safely and follow all safety protocols

·         All other duties as assigned by manager / supervisor

 

Minimum Qualifications: Biological Laboratory Experience

 

·         Bachelor’s with 5+ years OR Master’s with 2+ years of experience in cell line development, cell culture process development and/or manufacturing within a pharmaceutical/biotechnology company.

·         Direct experience in cell culture and knowledge of upstream bioprocessing.

·         Proficiency in core cell culture techniques.

·         Design of Experiments (DoE) experience and proven skills in statistical design and analysis.

·         Strong scientific writing skills and ability to communicate in a professional manner.

 

Working Conditions:
·         Work will be in shared office space in a typical office environment

·         Work will be in shared laboratory space in a typical chemical/ biological laboratory environment

·         Cell Culture work will be in a BSL II/III laboratory environment

 

Physical Demands & Work Environment:
·         High-volume cell culture and immunoassay development, must be able to perform repetitive tasks

·         Use of computer, phone, office equipment

·         Odor free environment (smoke-free, fragrance free)

·         Handling of chemicals/biologicals in a laboratory environment

·         Use of laboratory equipment (manual and electronic)

·         Ability to be on feet all day/sit for long periods of time

·         Long hours on a computer, typing and data entry. (Use of wrist and motor skills)

·         Driver’s License

·         Sight requirement

·         Able to lift 25 pounds

·         Use of stairs required

Application Scientist

Job Title: ApplicationScientist

 

Reporting Relationships: R/D Manager

Status: Full-time, Exempt Hours: Flexible Department: R/D

FLSA: Exempt

 

Job Summary & Purpose:
The Application scientist will plan, perform, report, present and trouble-shoot experiments under the guidance of a Senior Scientist or R/D Manager.  They will summarize and organize experimental data using their background in life sciences, cell biology/culture and biochemistry experience to meet the needs of the Research and Development team. Provide testing services and support production of immunoassay products. In addition, this position will focus on the research and development of novel protein array and antibody array technologies and products. Provide product information, including manuals, technical support documents and pricing information.

 

Essential Functions:
·         Microarray immunoassay development

·         Prepare materials as required

·         Perform quality control on production material.

·         Collaborate and communicate with cross-functional teams to support product development and quality control deliverables

·         Work safely and follow all safety protocols.

·         Communicate effectively and work well with others

·         All other duties as assigned by manager / supervisor

 

Minimum Qualifications: Biological Laboratory Experience

 

·         Bachelor’s with 5+ years of experience in biology, chemistry, or related discipline OR

·         Master’s with 2+ years of experience in biology, chemistry, or related discipline

·         Background in assay and technology development

·         Experience in cell culture and biology science preferred

·         Proven track record of troubleshooting and resolving issues at the interface of assays and instrumentation

·         Background in documentation and validation test planning and writing

·         Excellent quantitative analytical skills, including the ability to synthesize complex data sets and prepare summative reports

·         Proven ability to collaborate in a multi-disciplinary environment

·         Experience in the development and testing of complex biomedical products

·         Demonstrated ability in taking ownership of validation testing responsibilities with minimal supervision and guidance

·         Data-driven decision making

·         Detail oriented

 

Working Conditions:
·         Work will be in shared office space in a typical office environment

·         Work will be in shared laboratory space in a typical chemical/ biological laboratory environment

 

Physical Demands & Work Environment:
·         High-volume microarray and immunoassay development, must be able to perform repetitive tasks

·         Use of computer, phone, office equipment

·         Odor free environment (smoke-free, fragrance free)

·         Handling of chemicals/biologicals in a laboratory environment

·         Use of laboratory equipment (manual and electronic)

·         Ability to be on feet all day/sit for long periods of time

·         Long hours on a computer, typing and data entry. (Use of wrist and motor skills)

·         Driver’s License

·         Sight requirement

·         Able to lift 50 pounds

·         Use of stairs required

Operations Manager

Job Title: Operations Manager

 

Reporting Relationship: Controller

Status: Full-time, Exempt Hours: Flexible

Department: Operations

FLSA: Exempt

 

Job Summary & Purpose:
Provide, technical guidance, management, and oversight on a broad range of fiscal, operational and administrative systems between Finance, Customer Care, Manufacturing and Logistics.

 

Essential Functions:
Support defining and implementing the Customer Operations Strategy for key channels in alignment with the with Channel Sales & Channel Marketing strategies
Manage the Customer Care, Shipping and logistic team members and ensure staff performance, quality and productivity standards are met
Develop Planning, Purchasing and internal Supply Chain procedures and metrics ensuring efficient build of inventory stocking levels.
Identify and implement strategies to improve quality of service, productivity, and customer satisfaction; support strategic relationships to achieve and exceed assigned revenue targets and partner goals
Participate in budget planning and ensure that team activities adhere to cost strategy
Ensure a strong internal controls environment with a clear and well enforced standard for ethics and conduct
Promote a working team environment; ensure best practices are shared and followed; set team goals; develop and track key metrics; coach, counsel, train and manage performance
Effectively and efficiently identify and resolve customer issues and problems; serve as a point of escalation for customer issues requiring a higher degree of expertise or discretion
Capture and document the operational requirements of key channels, with respective steps to improve and/or grow business and partnerships. This includes reviewing requirement documents & contracts, summarizing applicable requirements in playbooks that are used to drive improvement plans and educate
Based on Customer requirements, work with the Sales Operations & Finance teams to track respective fines and identify actions to correct, as well as support the implementation
Review weekly/monthly/quarterly scorecards; identify opportunity areas
Ensure internal adoption and understanding of requirements with Sales, Marketing and Sales Operations
Support Quarterly Business Reviews, measuring partner performance against pre-established business metrics
Provide status reports on channel operations activities as they relate to customer scorecards, project activities and Company KPI’s
Develop and maintain daily, weekly, and monthly reports for management to make necessary business decisions
Maintain open communication through conversation and both formal and informal documents
Minimum Qualifications:
7 or more years of proven managerial and leadership experience
5 or more years of experience in customer service, channel operations, logistics utilizing ERP and MRP related systems
Planning experience highly preferred
Lean, Six Sigma, exposure to theory of constraints, certification or the equivalent a plus
Ability to work under pressure and achieve solutions in situations where there are conflicting objectives
Effective written and oral communication skills; able to communicate and influence effectively with all other functional areas and senior management; including experience writing and training to new procedures.
Solve problems analytically; search out relevant information and gauge its importance when making decisions
Solid business acumen with demonstrated knowledge and understanding of supply chain management processes such as forecasting, materials requirements planning, and procurement
Strategic and critical thinker in planning and action
Commitment to excellence in reporting and business support
Strong proficiency in Microsoft Office suite (Outlook, Word, Excel, PowerPoint) and data management software (Quickbooks preferred)
Available to work on site as required by job.
 

Working Conditions:

·         Work will be in shared office space in a typical office environment

 

 

Physical Demands & Work Environment:
·         Use of computer, phone, office equipment

·         Odor free environment (smoke-free, fragrance free)

·         Long hours on a computer with typing and data entry. (Use of wrist and motor skills)

·         Driver’s License

·         Sight Requirement

·         Walk between buildings (exterior movement)

·         Able to lift 50 pounds

·         Use of stairs required.

Controller

Job Title: Controller

 

Reporting Relationships: CEO

Status: Full-time, Exempt

Hours: Flexible

Department: Administration

FLSA: Exempt

 

Job Summary & Purpose:
As a member of Executive Leadership, the Controller will direct and manage all aspects of accounting and transactional operations related to    general ledger, receivables, payables, payroll, inventory, procurement, financial reporting and customer transactions. Will ensure revenue, journal entries and records are maintained in accordance with generally accepted accounting principles. Analyze interpret, and control accounting and financial activities. Ensure alignment between budgeting and overall company goals. Main interface with third party tax preparer, accounting, banking and legal partners. The controller manages accounting records and is responsible for the production of weekly, monthly, quarterly and annual financial reports, metrics and performance dash boards.

The controller oversees all employees involved in the accounting, order to cash and procure to pay business processes.

Essential Functions:
·         Report financial results, business risks, budgets and business strategies (both long term and short term) effectively to the Executive Team

·         Responsible for staffing and training finance and logistical positions with ongoing development as a team.

·         Oversee the preparation and analysis of all financial reporting materials and metrics; including departmental budgets,    revenue and expense forecasting as well as day-to-day transactional accounting

·         Forecasting cash flow and report status and strategy monthly

·         Ensure financial records are maintained in accordance with Generally Accepted Accounting Principles (GAAP)

·         Develop and monitor all global internal control procedures to ensure uniformity and conformity

·         Coordinate all audit activities

·         Coordinate all tax activities with third party tax return preparer

·         Manage all processes and systems administrative positions to ensure ERP system meets financial reporting, customer and                   management needs

·         Participate in the GBL Leadership Team, including cross-functional support of other departments

·         All other duties as assigned by manager / supervisor.

 

 

Minimum Qualifications:
·         Minimum 10 years experience in Accounting/Finance lead roles

·         Bachelor’s degree in Accounting or Finance

·         MBA or CPA desired, but not required

·         Ability to maintain confidentiality in all company financial and administrative matters

·         Strong communications ability

·         Strong systems experience with ERP systems, cost accounting, and general accounting

·         Ability to maintain a positive attitude amid potentially high-stress situations

·         Ability to multi-task/prioritize in an efficient and organized manner

·         Excellent spoken and written communication skills (English at minimum)

Working Conditions:
·         Work will be in shared office space in a typical office environment

 

Physical Demands & Work Environment:
·         Use of computer, phone, office equipment

·         Odor free environment (smoke-free, fragrance free)

·         Long hours on a computer with typing and data entry. (Use of wrist and motor skills)

 

Senior Vendor Manager

Position Overview:

The Platform Partner Management (PPM) team manages 3rd party vendor partners for Autodesk’s Cloud Platform (Forge). This includes cloud-native vendor partners across domains such as API Management, Security, Databases, SAAS/PAAS providers, Localization, Service and staff augmentation providers. The Senior Partner Manager is responsible for managing a variety of these vendor partner relationships including contracting, performance management, issue management, stakeholder management and being a key partner in risk and financial management.

Responsibilities:

Support specific areas of the business and manage all their vendor accounts
Create and manage vendor partner management policies and procedures. Ensure vendor compliance with Autodesk’s documented policies and procedures
Key stakeholder in vendor partner management lifecycle including sourcing, contracting, onboarding, participating in negotiations, issue management, to off-boarding
Work with Business, Strategic Sourcing, Procurement, and Security teams on RF(x) processes, technical vendor evaluations, security assessments, and other projects as needed
Work with Business, Procurement, Finance, and Legal teams to ensure contracts have appropriate terms and conditions, service level agreements, key performance indicators, and escalation processes
Responsible for contract management including compliance, oversight, and adherence to change control procedures. Monitor and ensure contract renewals are planned and executed well in advance of expiry
Monitor vendor partner performance, financial status, SLA/KPI monitoring. Drive and facilitate any disputes between business and supplier to resolution
Set up regular check-ins with vendor account managers, facilitate regular conversations between the business unit/stakeholder(s) and vendor operations teams
Plan and conduct regular business reviews and executive meetings at a cadence agreed with the business unit/stakeholder
Support the business in demand planning and monitor against the plan. Flag overages and additional budget asks well in advance
Partner with platform team to ensure all relevant vendor data is automated and available on dashboards

Minimum Qualifications:

10+ years of progressive experience in management of 3rd party vendor partner relationships critical to a cloud and platform technology business
Ability to work effectively in a team environment
Ability to effectively and comfortably communicate with executive leadership and provide updates/status reports or deliver presentations and recommendations
Excellent analytical, organizational, tactical and strategic planning, presentation (verbal, and written) communication skills
Ability to read and interpret legal documents such as contracts, terms and conditions, non-disclosure agreements
Ability to work with and empower others on a collaborative basis to ensure success of the PPM team
Ability to establish workflows, manage multiple projects, and meet necessary deadlines

Assistant/Associate Scientist

Sirona Dx is a technical CRO, in Portland Oregon founded to accelerate the pace of immunotherapy and targeted therapy development. While we invest in the development of technology to drive our innovations, our ongoing success relies on our team. We are looking to fill Full Time Assistant and Associate Scientist positions. These positions offer flexible hours and a rewarding work environment.

Primary Responsibilities:

Executes experiments, PCR and qPCR testing protocols and studies under protocols or the outlined direction of more senior R&D personnel.
Operate a variety of instruments and scientific platforms.
Collect, record, organize and verify the accuracy of data; keep detailed and accurate laboratory records; tabulate data, perform calculations, prepare charts, graphs, reports and manuscripts. *
Formulates reagents and developmental work in processes following CLIA laboratory practices as may be appropriate.
Ability to prioritize multiple tasks.
Ability to learn new methods quickly, to work independently and as part of a team while being collaborative in resolving problems.
Intermediate skills with Microsoft Office (Excel, Outlook, Access, Word, and PowerPoint)
Excellent communication, analytical and organizational skills: both written and verbal
Other duties may be assigned by supervisor.
Education and/or Experience:

B.A. or B.S. in Molecular Biology / Biochemistry / Immunology or similar discipline involving training in basic biology and chemistry.
·       3-5 years molecular and cellular biology or closely related discipline experience (PCR and qPCR testing are essential).

Understanding of working in a CLIA lab environment.
Histology lab experience is a plus.

Senior/Principal Scientist, Downstream Process Development

Absci is the drug and target discovery company harnessing deep learning and synthetic biology to expand the therapeutic potential of proteins. We translate ideas into drugs with a platform technology that reinvents the biopharmaceutical drug discovery process. We custom engineer E. coli to create novel complex biologics in their full-length format while simultaneously developing production cell lines. We are deploying cutting edge deep learning artificial intelligence to inform our designs, and every day we succeed in achieving things others have dismissed as impossible. Our collaborations with pharma and biotech partners include programs for drug candidates that range across multiple protein types and therapeutic indications. We are continually innovating and expanding the scope of our capabilities and potential impact with the hope of getting better drugs to patients at truly unprecedented speeds. We are based in Vancouver, Washington, ten minutes from Portland, Oregon within an hour of world class alpine terrain and rugged Pacific coastlines.

Job Description:

We are currently seeking a self-motivated, passionate, and accomplished Senior Scientist to join our Purification team. You will play an impactful role in downstream process development of therapeutic proteins expressed using SoluPro™, Absci’s proprietary E. coli expression platform. Leveraging your background and understanding of the modern DSP process toolbox, assay development, and high-throughput screening/chromatography technologies, you will develop and optimize purification processes to assure the final, purified material meets project deliverables. This position requires strong attention-to-detail and collaboration across multi-disciplinary teams within Absci, including Strain Construction, Fermentation, Analytical Development, and Data Science. Adding to the high-performance culture, your passion for scientific innovation, excellent technical skills, and initiative will make you successful in Absci’s brand new lab!

Responsibilities:

  • Develop downstream processes for large molecules including new biological entities and biosimilars
  • Identify key project challenges, effect creative solutions to advance project timelines
  • Operation, maintenance, and installation of instrumentation (e.g. AKTA, homogenizers, etc.)
  • Execute laboratory scale chromatography using associated instrumentation, (e.g. AKTA, FPLC, etc.), and downstream processes (e.g. buffer preparation, cell lysis/homogenization, TFF, filtration, etc.)
  • Write and review formal reports, includingSOPs and other technical documents
  • Capitalize on unique advantages of the SoluPro® host strain to innovate patentable process development and characterization technologies
  • Evaluate new technologies and implement high-throughput process development solutions

Qualifications:

  • PhD with 4+ years or MS with 6+ years of industry experience in process development
  • Industry experience developing downstream processes and performing tech transfer for biologics
  • Experience interpreting results from standard analytical techniques to assess product purity and clearance of process and product-related impurities
  • Proven expertise in statistical data analysis and Design of Experiment (DoE) applied in an industrial, biopharmaceutical environment
  • Proficient in software packages such as LIMS, ELNs (electronic lab notebooks), UNICORN, JMP, etc.
  • Can-do mind-set and the ability to adapt to change with strong communication and presentation skills
  • Passion for building a creative company culture that is collaborative, multidisciplinary, and determined to make a transformative impact to our industry
  • Demonstrated track record of working on teams cross-functionally to exceed goals

HUGE Plus (but not required):

  • Knowledge of cGMP, FDA, EMA, ICH guidances and industry standards for DSPD of biotherapeutic proteins to support clinical manufacturing
  • Expertise in statistical data analysis and Design of Experiment (DoE)
  • Experience mentoring and inspiring junior team members

We seek candidates who will dive into our creative company culture that’s collaborative, multidisciplinary, and committed to a big vision for positive impact. We are defying conventions and innovating without boundaries. We are disrupting an industry with bold ideas and passionate pursuit of new possibilities. We are looking for original thinkers, creative scientists, and data-devoted gurus. Successful candidates will be excited to work in a dynamic environment and contribute as a key member of a project team. If this sounds good to you, we invite you to join us in our quest to redefine possible.

Absci offers highly competitive salaries and benefits, including medical and dental insurance, paid time off, breakfast and lunch, and 401(k) with a generous company match. Legal authorization to work in the U.S. is required. Absci is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Absci will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Absci offers a dog-friendly work environment – bring your pup along for the ride.

Scientist I/II, Downstream Process Development

Absci is the drug and target discovery company harnessing deep learning and synthetic biology to expand the therapeutic potential of proteins. We translate ideas into drugs with a platform technology that reinvents the biopharmaceutical drug discovery process. We custom engineer E. coli to create novel complex biologics in their full-length format while simultaneously developing production cell lines. We are deploying cutting edge deep learning artificial intelligence to inform our designs, and every day we succeed in achieving things others have dismissed as impossible. Our collaborations with pharma and biotech partners include programs for drug candidates that range across multiple protein types and therapeutic indications. We are continually innovating and expanding the scope of our capabilities and potential impact with the hope of getting better drugs to patients at truly unprecedented speeds. We are based in Vancouver, Washington, ten minutes from Portland, Oregon within an hour of world class alpine terrain and rugged Pacific coastlines.

Job Description:

We are currently seeking a self-motivated, passionate, and accomplished Scientist to join our Purification team. You will play a significant role in downstream process development of therapeutic proteins expressed using SoluPro™, Absci’s proprietary E. coli expression platform. You will leverage your background and understanding of the modern DSP process toolbox, assay development, and high-throughput screening/chromatography technologies to develop and optimize purification processes to assure the final, purified material meets project deliverables. This position requires strong attention-to-detail and collaboration across multi-disciplinary teams within Absci, including Strain Construction, Fermentation, Analytical Development, and Data Science. You work with a sense of urgency and thrive in a dynamic team in a high-performance culture. Your passion for scientific innovation, excellent technical skills, and initiative in the lab will make you successful in Absci’s brand new lab!

Responsibilities:

  • Develop downstream processes for large molecules including new biological entities and biosimilars
  • Identify key project challenges, effect creative solutions to advance project timelines
  • Operation, maintenance, and installation  of ¥ instrumentation (e.g. AKTA, homogenizers, etc.)
  • Execute laboratory scale chromatography using associated instrumentation, (e.g. AKTA, FPLC, etc.), and downstream processes (e.g. buffer preparation, cell lysis/homogenization, TFF, filtration, etc.)
  • Write and review reports, includingSOPs and other technical documents

Qualifications:

  • PhD with 1+ years, MS with 4+ years or BS with 6+ years of industry experience in process development
  • Industry experience developing downstream processes for biologics
  • Experience performing and interpreting results from standard analytical techniques to assess product purity and clearance of process and product-related impurities
  • Proficient in software packages such as LIMS, ELNs (electronic lab notebooks), UNICORN, JMP, etc.
  • Can-do mind-set and the ability to adapt to change with strong communication and presentation skills
  • Passion for building a creative company culture that is collaborative, multidisciplinary, and determined to make a transformative impact to our industry
  • Demonstrated track record of working on teams cross-functionally to exceed goals

HUGE Plus (but not required):

  • Knowledge of cGMP, FDA, EMA, ICH guidances and industry standards for DSPD of biotherapeutic proteins to support clinical manufacturing
  • Proficient in statistical data analysis and Design of Experiment (DoE)
  • Experience evaluating new technologies and implementing high-throughput process development solutions

We seek candidates who will dive into our creative company culture that’s collaborative, multidisciplinary, and committed to a big vision for positive impact. We are defying conventions and innovating without boundaries. We are disrupting an industry with bold ideas and passionate pursuit of new possibilities. We are looking for original thinkers, creative scientists, and data-devoted gurus. Successful candidates will be excited to work in a dynamic environment and contribute as a key member of a project team. If this sounds good to you, we invite you to join us in our quest to redefine possible.

Absci offers highly competitive salaries and benefits, including medical and dental insurance, paid time off, breakfast and lunch, and 401(k) with a generous company match. Legal authorization to work in the U.S. is required. Absci is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Absci will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Absci offers a dog-friendly work environment – bring your pup along for the ride.

Scientist I/II Analytical Development (Separations or ELISA)

Absci is the drug and target discovery company harnessing deep learning and synthetic biology to expand the therapeutic potential of proteins. We translate ideas into drugs with a platform technology that reinvents the biopharmaceutical drug discovery process. We custom engineer E. coli to create novel complex biologics in their full-length format while simultaneously developing production cell lines. We are deploying cutting edge deep learning artificial intelligence to inform our designs, and every day we succeed in achieving things others have dismissed as impossible. Our collaborations with pharma and biotech partners include programs for drug candidates that range across multiple protein types and therapeutic indications. We are continually innovating and expanding the scope of our capabilities and potential impact with the hope of getting better drugs to patients at truly unprecedented speeds. We are based in Vancouver, Washington, ten minutes from Portland, Oregon within an hour of world class alpine terrain and rugged Pacific coastlines.

Job Description

We are currently seeking a self-motivated, passionate, and accomplished Scientist to join our Analytical Development team. You will play a significant role in analytical method development and characterization of therapeutic proteins expressed using SoluPro™, Absci’s proprietary E. coli expression platform. You will explore new and innovative technologies, oversee the routine instrument operation and maintenance, and train and mentor  junior personnel and personnel from other teams. The responsibilities of this role will utilize your interpersonal and strong written and verbal communication skills for multi-disciplinary collaboration with the other teams within Absci, including Strain Construction, High-Throughput Screening, Fermentation, Purification, and Data Sciences. You bring a passion for scientific innovation, excellent technical skills, and you execute your responsibilities with high attention to detail and a sense of urgency. You thrive in a team dynamic in a high-performance culture.

Responsibilities

  • Develop and execute laboratory tasks to support the development, optimization, and sample analysis of complex biologics by various chromatographic and electrophoretic separations techniques such as LC (e.g. LC-UV, SEC, IEX, etc.) and CE-SDS, including associated sample preparation techniques (e.g. desalting, sample concentration, protein denaturation or oxidation, etc.)
  • Operation, maintenance, and installation of sophisticated chromatography instrumentation (e.g. HPLC, CE, etc.)
  • Write and review formal reports, including method SOPs, reports, and other technical documents
  • Evaluate data for trends indicative of product performance, method performance, and/or analyst performance and present internally to team members and senior management
  • Evaluate new technologies and platforms
  • Use of software packages such as LIMS, ELNs (electronic lab notebooks), EMPOWER, JMP, etc.
  • Lead, mentor, and inspire junior team members
  • Support internal technical teams, including R&D, fermentation and purification process development teams
  • Maintain accurate documentation of all work in laboratory notebooks

Qualifications

  • PhD in Analytical Chemistry, Biochemistry, or related scientific discipline degree with 0 – 2 years of industry or post-doc experience, or Master’s with equivalent experience
  • Proven experience in method development, testing, and qualifications/ validations
  • Comprehensive hands-on knowledge of protein analytics and characterization, including LC (e.g. LC-UV, SEC, IEX, etc.) and CE-SDS OR knowledge of immunoassay methods for quantification, impurity detection and potency determination of protein samples, including ELISA, BLI and SPR
  • Experience in relevant sample preparation techniques including desalting, buffer exchange, proteolytic digestion, deglycosylation, reduction, alkylation, etc.
  • Experience in the operation, maintenance, and troubleshooting of associated instrumentation
  • Ability to design and execute experiments; review and interpret data
  • Excellent problem-solving and troubleshooting skills
  • Experience in using software packages such as LIMS, ELNs (electronic lab notebooks), EMPOWER, SoftMax Pro, JMP, etc., is preferred

Huge plus (but not required):

  • Post-Doc and/or industry experience
  • Previous experience with automation and high-throughput screening
  • Previous experience in the analysis of ADCs is a plus
  • Experience in using software packages such as LIMS, ELNs (electronic lab notebooks), EMPOWER, JMP, etc.

We seek candidates who will dive into our creative company culture that’s collaborative, multidisciplinary, and committed to a big vision for positive impact. We are defying conventions and innovating without boundaries. We are disrupting an industry with bold ideas and passionate pursuit of new possibilities. We are looking for original thinkers, creative scientists, and data-devoted gurus. Successful candidates will be excited to work in a dynamic environment and contribute as a key member of a project team. If this sounds good to you, we invite you to join us in our quest to redefine possible.

Absci offers highly competitive salaries and benefits, including medical and dental insurance, paid time off, breakfast and lunch, and 401(k) with a generous company match. Legal authorization to work in the U.S. is required. Absci is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Absci will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Absci offers a dog-friendly work environment – bring your pup along for the ride.

Technical Sales & Support Rep

In this Customer Facing Role, the TSR will provide daily technical support to users by researching and answering questions regarding the GBL portfolio and applications; troubleshooting problems; maintaining strong relationships and identifying opportunities for future technology and partnerships.

Commercial Manager

Under the direction of Executive Management the Commercial Manager will manage the short and long-term product lifecycle roadmap according to business strategy to include evaluation of technology, price elasticity, portfolio  health, marketing channels and competitiveness.

Executive Assistant

The Scientist, Cell Culture will serve as a lead for all cell culture projects. The successful candidate will work cross-functionally with other members of the R&D team to ensure successful customer project outcomes. This highly motivated individual will plan, perform, report, present and trouble- shoot experiments under the guidance of a Senior Scientist or R/D Manager. Summarize and organize experimental data. Provide testing services and support production of immunoassay products including product information, manuals, technical support documents and pricing information.

 

Clinical Program Manager

Sparrow Pharmaceuticals is a biopharmaceutical company determined to discover, develop, and deliver innovative therapies that target toxic cortisol levels and unlock the potential of corticosteroid medicines such as prednisone. Sparrow is led by an experienced team of scientific thinkers, disruptors and entrepreneurs. We are developing novel therapies to address the key limitations of treatments for endogenous Cushing’s syndrome (Cushing’s), autonomous cortisol secretion (ACS), and polymyalgia rheumatica (PMR). Backed by world-class investors, we are prepared to take our medical products through the entire development continuum – from clinical trials through regulatory approval to commercialization.

 

Job Summary:

The incumbent will be responsible for ensuring the delivery execution of clinical studies in one or more therapeutic areas, in adherence to Good Clinical Practices (GCPs), appropriate Standard Operating Procedures (SOPs), Food and Drug Administration (FDA) regulations/EU Directive, and International Conference on Harmonization (ICH) guidelines.

 

The Clinical Project Manager (CPM) will have demonstrated ability to oversee all operational aspects of Phase I-III clinical trials with minimal oversight to achieve a high-quality study data for the regulatory submission, commercialization and business success for Sparrow.

 

Essential Job Functions:

 

Study Management & Leadership

Ability to oversee multiple clinical studies and CRO vendors
Reports on key study performance information and cycle time metrics pertaining to time, cost and quality deliverables, e.g., study start-up metrics, enrollment, data collection timeliness, etc.
Leads the development of the clinical study plan including critical path activities and interdependencies for assigned clinical study
Provides operational input into study protocols, informed consent and amendments
Assists in the review and or development of the core study documents, plans and processes.
Proactively assesses potential risks to the study and proposes risk mitigation plans.
Provides study specific oversight of site feasibility, enrollment projections and site identification activities.
Develops and drives study timelines, milestones, site and study level budgets and accountable for providing monthly and yearly financial estimates. Responsible for tracking study budget and payments and forecasting study spend.
Reviews and approves site and vendor invoices, including investigator grants and pass-through costs.
Ensures oversight of TMF with periodic audits
Verifies that all relevant IT-systems are updated with current and accurate information (e.g., CTMS, eTMF).
Ensures compliance to regulatory and GCP, and internal processes
Plans and coordinates IMP and non-IMP supplies
Contributes to development of proactive strategies and corrective action plans as needed to address study issues
Identifies, implements, leads and manages a cross-functional Team for the duration of the study, working with management to identify team members and resolve issues and disseminates relevant information to team members in effective and timely manner.
Triages, resolves and/or escalates study issues /risk mitigations to Head of Clinical Operations
Has routine interaction with key internal and external stakeholders communicating project status, escalating issues, and troubleshooting routine inquiries
Responsible for the oversight, performance, and management of CROs and vendors to ensure compliance with quality measures and adherence to scope of work within timelines and budget at a task level. Specifically tracks operational study timelines and monitors operational performance metrics through the life of the study; Identifies issues and proposes solutions.
Responsible for ensuring that vendors provide timely input and generate documents in a timely manner and with quality.
Responsible for overseeing CRO to ensure that essential site documents are collected, and sites are initiated per study plan, enrollment is on target and mitigation plans are in place.
Coordinates, prepares for and executes meetings including but not limited to team meetings, investigator meetings and training.
Helps to ensure team and external partner(s) receive and document study specific training
Other tasks as assigned
Experience / Education

A Bachelor’s degree (life science preferred) or certification in a related allied health profession (i.e., nursing, medical or laboratory technology) from an appropriately accredited institution
7 – 8 years of increasing responsibility in industry clinical operations including at least 3 years clinical operations experience as study or program lead, and direct experience in global (ex-US) multicenter trials.
2 – 3 years of Monitoring experience preferred.

 

Knowledge / Skills / Abilities:

Knowledge of all phases of drug development: Phase I – IV global clinical trials
Extensive and comprehensive knowledge of Good Clinical Practice (GCP), Federal Regulations and International Regulations (International Harmonization Committee-ICH Regulations).
Demonstrated ability to comprehend complex scientific concepts and data. Proficient in reviewing and assessing clinical data.
Excellent interpersonal and decision-making skills. Demonstrates innovation. Possesses drive, energy, and enthusiasm to deliver the program objectives
Demonstrated project management skills including simultaneous management of multiple projects. Possesses excellent planning, time management & coordination skills.
Demonstrated ability to problem solve and use clear judgment in relation to regulatory requirements, interactions with external parties, timelines, and complex clinical programs.
Excellent written and oral communication skills.
Maintains computer literacy in appropriate software

Research Scientist/Postdoc

Nzumbe is a life sciences company focused on epigenetic dysregulation in disease development. We leverage our expertise in epigenetics to develop innovative drug discovery platforms and novel therapeutic strategies to target epigenetic changes in disease.

As a Research Scientist/Postdoc, you will be part of a small, fast-paced and dynamic team. The primary focus of this position is to work on the development and commercialization of unique therapeutic strategies and in vitro assays applicable to a variety of diseases ranging from cancer to neuropsychiatric disorders. This position seeks an individual who is a self-starter and finds reward in solving technical and intellectual problems while contributing to the advancement of technologies that have potential to yield insight into complex human disease. Beyond the competitive pay and excellent benefits, there are multiple opportunities for professional growth and advancement given the small and dynamic nature of the company.

Essential Duties and Responsibilities will include:

  • Design, perform and analyze experiments that advance technologies in the development pipeline
  • Contribute to strategic validation and development of technologies that identify and therapeutically target epigenetic factors underlying disease
  • Supervisory responsibilities for laboratory technical staff working on related projects
  • Maintain thorough and accurate lab records.
  • Contribute to progress reports, presentations, and manuscripts by gathering, organizing, and interpreting data.
  • Confer with other scientific personnel; attend seminars and technical meetings.

Essential Qualification/Skill Sets:

  • PhD in Molecular Biology, Biochemistry, Neuroscience or related area of study
  • Work experience in a scientific research laboratory
  • Drive to make meaningful contributions
  • Strong analytical ability and organizational skills
  • Accurate bench work, record keeping, data interpretation
  • Ability to set priorities, exercise discretion and independent judgment, and manage high production volume
  • Ability to work both independently and in a team environment
  • Strong verbal and writing skills

Bonus Skills/Experience:

  • Cell culture
  • Experience w/ human induced pluripotent stem cells (iPSCs) & neural progenitor cells (NPCs)
  • Molecular cloning
  • High-throughput assay development (e.g. luciferase assays)
  • Experience working with mice.

Nzumbe offers an entrepreneurial work environment. We value and reward excellence, contribution, and creativity in our efforts to achieve our mission. We strive to seek the best in people and implement innovative, effective strategies.

Nzumbe is an Equal Opportunity Employer offering an excellent compensation package that includes comprehensive benefits, and a relaxed environment that promotes personal and professional growth.

Send letter of interest and CV/resume with RESEARCH SCIENTIST in the subject line, to info@nzumbeinc.com.

Research Technician

Nzumbe is a life sciences company focused on epigenetic dysregulation in disease development. We leverage our expertise in epigenetics to develop innovative drug discovery platforms and novel therapeutic strategies to target epigenetic changes in disease.

As a Research Technician, you will be part of a small, fast-paced and dynamic team. The primary focus of this position is to work on the development and commercialization of innovative therapeutic strategies and unique in vitro assays applicable to a variety of diseases ranging from cancer to neuropsychiatric disorders. This position seeks an individual who is a self-starter and finds reward in solving technical and intellectual problems while contributing to the advancement of technologies that have potential to yield insight into complex human disease. Beyond the competitive pay and excellent benefits, there are multiple opportunities for professional growth and advancement given the small and dynamic nature of the company.

Essential Duties and Responsibilities will include:

  • Prepare laboratory reagents, chemicals, stocks, cultures and cell lines.
  • Operate laboratory instruments (e.g. centrifuges, plate readers, PCR thermal cyclers).
  • Perform chemical or biological analyses following written protocols.
  • Maintain thorough and accurate lab records.
  • Conduct routine tasks such as lab inventory and ordering.
  • Conduct experimental protocols with minimal instruction.
  • Contribute to progress reports, presentations, and manuscripts by gathering, organizing, and interpreting data.
  • Confer with other scientific personnel; attend seminars and technical meetings.

Essential Qualification/Skill Sets:

  • BS/BA in Molecular Biology, Biochemistry or related area of study
  • Work experience in a scientific research laboratory
  • Strong analytical ability and organizational skills
  • Accurate bench work, record keeping, data interpretation
  • Ability to set priorities, exercise discretion and independent judgment, and manage high production volume
  • Ability to work both independently and in a team environment
  • Strong verbal and writing skills

Bonus Skills/Experience:

  • Cell culture
  • Experience w/ human induced pluripotent stem cells (iPSCs) & neural progenitor cells (NPCs)
  • Molecular cloning
  • High-throughput assay development (e.g. luciferase assays)
  • Experience working with mice.

Nzumbe offers an entrepreneurial work environment. We value and reward excellence, contribution, and creativity in our efforts to achieve our mission. We strive to seek the best in people and implement innovative, effective strategies.

Nzumbe is an Equal Opportunity Employer offering an excellent compensation package that includes comprehensive benefits, and a relaxed environment that promotes personal and professional growth.

Send letter of interest and CV/resume with RESEARCH TECHNICIAN in the subject line, to info@nzumbeinc.com.